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Carbamoylsilanes from the in situ metalation–silylation of a formamide

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
42
Issue
8
Identifiers
DOI: 10.1016/s0040-4039(00)02275-9
Keywords
  • Metalation–Silylation
  • Carbamoylsilanes
  • Carbamoyllithium
  • Silyl Group Exchange

Abstract

Abstract In situ treatment (−78°C) of N-methoxymethyl– N-methylformamide and chlorotrimethylsilane with LDA affords synthetically useful yields of the carbamoylsilane. The latter undergoes silyl group exchange at 145°C in the presence of a chlorosilane and CsF.

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