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Anticonvulsant effects of ipsilateral but not contralateral microinjections of the dopamine D2agonist LY 171555 into the nucleus accumbens of amygdala-kindled rats

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
553
Issue
2
Identifiers
DOI: 10.1016/0006-8993(91)90822-d
Keywords
  • Epilepsy
  • Kindling
  • Dopamine
  • Nucleus Accumbens
  • Mesolimbic System

Abstract

Abstract Recent radioligand binding studies demonstrated an increase in the density of dopamine D 2 receptors in the nucleus accumbens ipsilateral to the stimulating electrode in amygdala- or hippocampal-kindled rats. In the present study we examined the anticonvulsant effect of dopamine agonists by unilateral microinjections into the nucleus accumbens in rats kindled from the right basolateral amygdaloid nucleus. Microinjections of the D 2 agonist LY 171555 into the ipsilateral nucleus accumbens 15 min prior to the kindling stimulation in fully kindled rats decreased significantly kindling parameters such as seizure severity, seizure duration and afterdischarge duration, whereas the D 1 agonist SKF 38393 had no anticonvulsant effects. After ipsilateral microinjection of 40 pmol LY 171555, focal and generalized kindled seizures were totally blocked in almost 50% of the rats. The anticonvulsant effect of LY 171555 could be completely antagonised by systemic administration of the D 2 antagonist sulpiride. Microinjection of the D 1 or D 2 agonist into the nucleus accumbens contralateral to the stimulating electrode had no anticonvulsant effects. In accordance with other reports our data indicate a possible topographic limitation of D 2 receptor mediated anticonvulsant effects to specific regions of the basal ganglia.

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