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Gut intraepithelial lymphocyte development

Authors
Journal
Current Opinion in Immunology
0952-7915
Publisher
Elsevier
Publication Date
Volume
14
Issue
2
Identifiers
DOI: 10.1016/s0952-7915(02)00330-8
Keywords
  • Lymphocyte Development

Abstract

Abstract CD8αβ + and CD4 + intraepithelial lymphocytes, the progeny of double-positive thymocytes, are oligoclonal T-cell populations that have accumulated in the gut wall as the result of repeated antigenic stimulations, which lead to rounds of traffic through the lymph/blood circuit ending in an α4β7-integrin-driven homing all along the gut mucosa. In contrast, CD8αα + intraepithelial lymphocytes, which may be TCRγδ + or αβ +, result in part from local differentiation in the gut, but studies comparing euthymic and athymic mice suggest a thymic double-negative origin for many of them.

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