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Regulation of ornithine-[delta]-aminotransferase in retinoblastomas

Authors
Publisher
McGill University
Publication Date
Keywords
  • Aminotransferases.
  • Retinoblastoma.
  • Genetic Regulation.
  • Ornithine Aminotransferase
Disciplines
  • Biology

Abstract

OAT transcription and mRNA levels in the two lines were similar, but 3-fold greater immunoreactive OAT protein and enzyme activity were observed for Y79. Characterization of polysome-associated OAT mRNAs indicated that they were translated less efficiently, due to decreased initiation, in RB355. Initiation factor eIF-4E mRNA and protein were reduced in RB355; eIF-4E overexpression in RB355 increased OAT translation and OAT protein to the level observed in Y79.

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