Affordable Access

Publisher Website

Upregulated BclGLexpression enhances apoptosis of peripheral blood CD4+T lymphocytes in patients with systemic lupus erythematosus

Authors
Journal
Clinical Immunology
1521-6616
Publisher
Elsevier
Publication Date
Volume
132
Issue
3
Identifiers
DOI: 10.1016/j.clim.2009.05.010
Keywords
  • Systemic Lupus Erythematosus
  • Cd4+T Lymphocytes
  • Bclgl
  • Apoptosis
Disciplines
  • Biology

Abstract

Abstract Increased lymphocyte apoptosis has been suggested to contribute to the development of systemic lupus erythematosus (SLE), but the critical factors involved in the apoptotic pathways are still unknown. By long serial analysis of gene expression (LongSAGE) profiles and microarray analyses, a novel apoptosis-related gene BclG L expression was found significantly increased in peripheral blood CD4 + T cells of SLE patients, which was correlated with the enhanced CD4 + T cells apoptosis, anti-nuclear antibody (ANA) titer and proteinuria. In vitro, BclG L expression could be specially upregulated by SLE serum stimulation and positively correlated with induced CD4 + T cell apoptosis. Enforcing BclG L overexpression by lentivirus could directly enhance CD4 + T cell apoptosis, but these apoptosis-inducing effects could be partially inhibited by knockdown of BclG L expression. Collectively, these results indicate that increased BclG L expression may contribute to the aberrant CD4 + T cell apoptosis which causes an inappropriate immune response and impaired homeostasis in SLE.

There are no comments yet on this publication. Be the first to share your thoughts.