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Altering the chromatin landscape for nucleotide excision repair

Authors
Journal
Mutation Research/Reviews in Mutation Research
1383-5742
Publisher
Elsevier
Publication Date
Volume
682
Issue
1
Identifiers
DOI: 10.1016/j.mrrev.2009.01.002
Keywords
  • Dna Damage
  • Excision Repair
  • Chromatin
  • Histone Modification
  • Histone Mutants
Disciplines
  • Biology

Abstract

Abstract DNA acts as a ‘workbench’ for various nuclear processes that occur inside living cells. In eukaryotic cells, DNA is highly compacted in a structural hierarchy with histones and other proteins into chromatin. This compaction affects DNA structure and coordinates the accessibility to site-specific nuclear factors during DNA processing events. DNA repair is no exception to this general rule and several reviews have appeared recently that discuss this topic in detail [1–3]. Here, we focus on recent findings correlating changes in DNA repair with subtle variations in the chromatin landscape.

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