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Characterization of a Small Plasmid Determining Resistance to Erythromycin, Lincomycin, and Vernamycin Bα in a Strain of Streptococcus sanguis Isolated from Dental Plaque

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  • Biosynthesis
  • Chemistry
  • Mechanisms Of Action And Resistance
  • Design
  • Medicine


A plasmid determining resistance to erythromycin (inducible), lincomycin, and vernamycin Bα was isolated from a strain of Streptococcus sanguis isolated from dental plaque of a patient who had been on erythromycin therapy for an extended period of time. The plasmid, designated pAM77, had a molecular weight of 4.5 × 106 and was present to the extent of one to two copies per bacterial chromosome. The plasmid could transform S. sanguis strain Challis.

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