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Ketamine protects cultured neocortical neurons from hypoxic injury

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
380
Issue
1
Identifiers
DOI: 10.1016/0006-8993(86)91447-2
Keywords
  • Glutamate
  • Ketamine
  • Cyanide
  • Cell Culture
  • Hypoxia
  • Cell Death
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl- d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

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