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Mechanisms and consequences of replication fork arrest

Authors
Journal
Biochimie
0300-9084
Publisher
Elsevier
Publication Date
Volume
82
Issue
1
Identifiers
DOI: 10.1016/s0300-9084(00)00344-8
Keywords
  • Replication Fork Barrier
  • Replication Fork Pausing Site
  • Replication Termination
  • Recombination
  • Genome Instability
Disciplines
  • Biology
  • Mathematics

Abstract

Abstract Chromosome replication is not a uniform and continuous process. Replication forks can be slowed down or arrested by DNA secondary structures, specific protein-DNA complexes, specific DNA-RNA hybrids, or interactions between the replication and transcription machineries. Replication arrest has important implications for the topology of replication intermediates and can trigger homologous and illegitimate recombination. Thus, replication arrest may be a key factor in genome instability. Several examples of these phenomena are reviewed here.

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