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Arachidonic acid and prostaglandins enhance potassium-stimulated calcium influx into rat brain synaptosomes

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
29
Issue
9
Identifiers
DOI: 10.1016/0028-3908(90)90156-l
Keywords
  • Arachidonic Acid
  • Brain
  • Calcium
  • Prostaglandins
  • Synaptosomes

Abstract

Abstract Exogenous administration of arachidonic acid, prostaglandins PGF 2α, PGD 2 and PGE 2 increased potassium-stimulated uptake of calcium in rat brain synaptosomes from the brain of the rat, but had no effect on the basal uptake of calcium. Arachidonic acid-induced uptake of calcium was mediated by its prostaglandin metabolites, because a cylooxygenase inhibitor, indomethacin, inhibited the response. l-Type calcium channel blockers, such as verapamil, diltiazem and nimodipine, blocked both KCl- and prostaglandin-enhanced potassium-stimulated influx of calcium in the brain. These results suggest that prostaglandins act as a calcium ionophore, through l-type voltage-sensitive calcium channels.

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