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Synthesis of 1-phosphonoalkylidene and -arylidene derivatives of nucleosides

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
37
Issue
20
Identifiers
DOI: 10.1016/0040-4039(96)00562-x

Abstract

Abstract Redox reaction of chlorodiethylphosphite with nucleoside orthoesters results in efficient synthesis of 2′, 3′- or 3′, 5′-O-((1-diethylphosphono)aralkyl)methylene derivatives of nucleosides as a novel type of isopolar phosphonate-based nucleotide analogues. The configuration of products was determined by 2D-ROESY NMR experiments.

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