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Synthesis of some new 1,4-benzothiazine and 1,5-benzothiazepine tricyclic derivatives with structural analogy with TIBO and their screening for anti-HIV activity# # A preliminary account of this work was presented at the 4th International Conference on Heteroatom Chemistry, Seoul, Korea, July 30–August 4, 1995

Authors
Journal
European Journal of Medicinal Chemistry
0223-5234
Publisher
Elsevier
Publication Date
Volume
34
Issue
9
Identifiers
DOI: 10.1016/s0223-5234(99)00223-8
Keywords
  • 1
  • 4-Benzothiazine And 1
  • 5-Benzothiazepine Derivatives
  • Anti-Hiv-1 Activity
  • Non-Nucleoside Reverse Transcriptase Inhibitor (Nnrti)

Abstract

Abstract Several new tricyclic derivatives with structural analogy to TIBO were prepared starting from properly substituted 1,4-benzothiazines and 1,5-benzothiazepine. All synthesized compounds were submitted to screenings for in vitro anti-HIV-1 activity. Only two compounds showed moderate activity.

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