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Optically active fluorinated cyclobutane nucleoside analogs with potent anti-herpes activity

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
3
Issue
6
Identifiers
DOI: 10.1016/s0960-894x(00)80318-2

Abstract

The synthesis and antiherpes activity of several optically active 4′-fluoro-2′,3′-dihydroxy-methylcyclobutyl nucleoside analogs (e. g. ( −) −1) is described. The key step is a diastereoselective [2+2] cycloaddition of a novel fluoroketene acetal 6 with (−)-dimenthyl furmarate.

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