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Neurotransmitter-caused increase in [3H]inositol incorporation into phosphatidylinositol de novo synthesisvsexchange

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
162
Issue
1
Identifiers
DOI: 10.1016/0014-5793(83)81064-3
Keywords
  • Phosphatidylinositol αAdrenergic Muscarinic Receptors Rat Parotid

Abstract

Abstract [ 3H]inositol and 32P i were simultaneously incorporated into rat parotid phosphatidylinositol. The ratio of [ 3H]/ 32P i incorporation dropped dramatically following stimulation with muscarinic or α-adrenergic agonists and returned to control values following the addition of appropriate antagonists. The drop in [ 3H]/ 32P i ratio can be explained by a rapid increase in de- novo synthesis of phosphatidylinositol following its receptor-mediated breakdown. The change in this ratio also provided evidence for the existence of CDP-DG + inositol ⇄ phosphatidylinositol exchange reaction in the intact tissue.

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