Publisher Summary This chapter provides a summary of the work that has led to the current day understanding of conventional aqueous outflow. The anatomy and basic physiology of aqueous humor outflow through the trabecular meshwork, through Schlemm's canal, to the episcleral venous system are reviewed. Various postulates concerning the manner in which aqueous outflow resistance is generated are reviewed as well. The focus of this chapter is on the conventional outflow pathway. It begins with an examination of the aqueous humor itself. Then, it briefly discusses the flow resistance of those aspects of the outflow pathway that are thought to have minor roles in the generation of aqueous outflow resistance. Finally, this chapter focuses on the region near the inner wall of Schlemm's canal where the bulk of outflow resistance is thought to be generated.