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Stabilisation of beta and gamma oscillation frequency in the mammalian olfactory bulb

Authors
Journal
BMC Neuroscience
1471-2202
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
12
Identifiers
DOI: 10.1186/1471-2202-12-s1-p362
Keywords
  • Poster Presentation

Abstract

Stabilisation of beta and gamma oscillation frequency in the mammalian olfactory bulb POSTER PRESENTATION Open Access Stabilisation of beta and gamma oscillation frequency in the mammalian olfactory bulb Nicolas Fourcaud-Trocmé1,2*, Emmanuelle Courtiol1,2, Nathalie Buonviso1,2, Thomas Voegtlin3 From Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011 The dynamics of the mammalian olfactory bulb (OB) is characterized by local field potential (LFP) oscillations either slow, in the theta range (2-10Hz, tightly linked to the respiratory rhythm), or fast, in the beta (15-30Hz) or gamma (40-90Hz) range. These fast oscillations are known to be modulated by odorant features [1] and ani- mal experience or state [2][3], but both their mechan- isms and implication in coding are still not well understood. In this study, we used a double canulation protocol to impose artificial breathing rhythms to anesthetized rats while recording the LFP in the OB. We observed that despite the changes in the input air flow parameters (frequency or flow rate), the main char- acteristics of fast oscillations (duration, frequency or amplitude) were merely constant. We thus made the hypothesis that fast beta and gamma oscillations dynamics are entirely determined by the OB network properties and that external stimulation was only able put the network in a state which permits the generation of one or the other oscillations (they are never present simultaneously). To test this hypothesis, we studied a simplified OB model based on previous modeling studies. In particular it includes resonant mitral cells [4] and graded synaptic inhibition [5]. Detailed analysis and numerical simula- tions of the model showed that two oscillatory dynami- cal regime can be sustained. First, a low noise regime where at each cycle, a subset of mitral cells are tightly synchronized and yield a saturation of the graded inhibition, during which mitral cell discharge is prevented. Because o

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