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High efficiency of Biozzi's high responder mouse strain in the generation of antibody secreting hybridomas

Authors
Journal
Journal of Immunological Methods
0022-1759
Publisher
Elsevier
Publication Date
Volume
38
Identifiers
DOI: 10.1016/0022-1759(80)90270-7

Abstract

Abstract While preparing monoclonal antibodies against human lymphocyte surface antigens, we compared two strains of mice, which had been genetically selected by Biozzi et al. (1970) for their high and low antibody responses to sheep erythrocytes. Biozzi et al. (1975) subsequently showed that these high and low responder strains (HR and LR) have a high and low antibody response to almost any antigen. We observed with the HR strain a huge increase in the number of hybrids secreting an antibody directed against human lymphocytes.

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