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Nickel and Cadmium Ions Inhibit Quorum Sensing and Biofilm Formation Without Affecting Viability inBurkholderia multivorans

Authors
Journal
International Biodeterioration & Biodegradation
0964-8305
Publisher
Elsevier
Volume
91
Identifiers
DOI: 10.1016/j.ibiod.2014.03.013
Keywords
  • Biofilm
  • Microbial Influenced Corrosion
  • Acyl-Homoserine Lactone
  • Quorum Sensing
  • Heavy Metals
Disciplines
  • Ecology
  • Geography

Abstract

Abstract Microbial influenced corrosion (MIC) and biofouling are multi-billion dollar challenges typically associated with bacterial biofilms. Using microtiter plate and quantitative reverse transcriptase polymerase chain reaction (q-PCR) assays, we show that sub-millimolar concentrations of nickel (Ni2+) and cadmium (Cd2+) inhibit biofilm formation by the bacterium Burkholderia multivorans through the inhibition (at the transcriptional level) of acyl-homoserine lactone quorum sensing (QS). These results advance the understanding of environmental factors influencing the establishment and subsequent development of biofilms, as this is the first paper linking heavy metals with quorum sensing and biofilm inhibition, and may guide strategies to mitigate MIC and biofouling of infrastructure surfaces.

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