Affordable Access

Publisher Website

Anorexia nervosa: Evidence for a genetic basis

Authors
Journal
Journal of Psychosomatic Research
0022-3999
Publisher
Elsevier
Publication Date
Volume
32
Issue
6
Identifiers
DOI: 10.1016/0022-3999(88)90004-9
Disciplines
  • Ecology
  • Geography
  • Medicine

Abstract

Abstract This paper reports the preliminary results of a combined twin and family study of anorexia nervosa. Fifty-six per cent of the 25 female monozygotic (MZ) twin pairs and 5% of the 20 female dizygotic (DZ) twin pairs were concordant for anorexia nervosa. Nearly 5% of other female first degree relatives also had a history of anorexia nervosa. Analysis of data from the Eating Disorders Questionnaire (EDI) given to the twins and data as to weight loss, length of amenorrhoea and other characteristics of anorexia nervosa, together with the twin and family data, supports the hypothesis that genetic factors are very significant in the aetiology of anorexia nervosa. Analysis of this data using established techniques of psychiatric genetics suggested that up to 80% of the variance in liability to anorexia nervosa may be accounted for by genetic factors. The problems of this type of analysis are discussed as is the background to the genetics of weight and appetite control. A genetic/environmental model accounting for the features of anorexia nervosa is proposed.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Anorexia nervosa: evidence for a genetic basis.

on Journal of Psychosomatic Resea... 1988

The genetics of anorexia nervosa.

on Clinical pharmacology and ther... February 2012

The genetics of anorexia nervosa.

on Annual review of nutrition 2007

Generalized anxiety disorder and anorexia nervosa:...

on Depression and anxiety August 2011
More articles like this..