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Stimulation of cellular RNA synthesis in mouse-kidney cell cultures infected with SV40 virus

Authors
Journal
Experimental Cell Research
0014-4827
Publisher
Elsevier
Publication Date
Volume
100
Issue
2
Identifiers
DOI: 10.1016/0014-4827(76)90175-0

Abstract

Abstract In confluent primary mouse-kidney cell cultures, abortive infection with SV40 has been demonstrated to cause an increase in the bulk of cellular RNA (mainly rRNA). However, the increase in the rate of rRNA synthesis is not involved in the initiation of the virus-induced cellular DNA replication since after actinomycin D treatment (0.05 μg/ml, from 6 to 9 h p.i.) the onset of cellular DNA replication takes place at a time when the rate of rRNA synthesis is still depressed.

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