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The dependence of the Chou-Fasman parameters on amino acid side chain structure

Authors
Journal
Journal of Theoretical Biology
0022-5193
Publisher
Elsevier
Publication Date
Volume
102
Issue
1
Identifiers
DOI: 10.1016/0022-5193(83)90265-5
Disciplines
  • Biology

Abstract

Abstract The Chou-Fasman conformational parameters, P, for amino acid residues in proteins are shown to be a linear function of intermolecular force and steric parameters. For α- helix, coil and turn parameters, steric effects are predominant; whereas for β-sheet parameters, intramolecular forces are predominant. Turn and coil parameters show little or no difference in their dependence which is different from that of α-helix and in some ways almost reciprocal. Factors which increase the probability of finding an amino acid residue in an α-helix usually decrease the probability of finding it in coil or turn. Values of P were calculated for several of the less common amino acids.

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