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CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.

Authors
  • 1
Type
Published Article
Journal
Journal of immune based therapies and vaccines
1476-8518
Publication Date
Volume
6
Pages
6–6
Identifiers
DOI: 10.1186/1476-8518-6-6
PMID: 18957084
Source
Medline

Abstract

Antibody (Ab)-mediated inhibition of the most abundant serum CXCR3 ligand, CXCL10, in mice decreased the local production of CXCR3 ligands as well as Th1 cytokines expressed by local leukocytes, and lowered corresponding serum levels to reduce the severity of CYP-induced cystitis. The present study is among the first to demonstrate some of the cellular and molecular mechanisms of chemokines in cystitis and may represent new drug target for this disease.

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