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The early synthesis of RNA in polyoma virus development

Authors
Journal
Virology
0042-6822
Publisher
Elsevier
Publication Date
Volume
29
Issue
1
Identifiers
DOI: 10.1016/0042-6822(66)90194-2
Disciplines
  • Medicine

Abstract

Abstract The synthesis of RNA during polyoma virus (PV) development has been studied by the use of 6-azauridine in the presence of added deoxycytidine and thymidine. The results indicate that the RNA required for PV development was present in infected mouse embryo cells by about 9 hours after infection, i.e., about 14 hours before virions were first detected; and that RNA synthesis was required for the synthesis of infectious DNA as well as for the production of viral antigen and virions.

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