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1.5 and 3 Tesla quantification of myocardial perfusion reserve in comparison to fractional flow reserve

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
15
Identifiers
DOI: 10.1186/1532-429x-15-s1-p199
Keywords
  • Poster Presentation
Disciplines
  • Medicine

Abstract

1.5 and 3 Tesla quantification of myocardial perfusion reserve in comparison to fractional flow reserve POSTER PRESENTATION Open Access 1.5 and 3 Tesla quantification of myocardial perfusion reserve in comparison to fractional flow reserve Peter Bernhardt*, Thomas Walcher, Wolfgang Rottbauer, Jochen Wöhrle From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013 Background Quantitative myocardial perfusion reserve (MPR) analy- sis is capable of noninvasive detection of significant cor- onary artery disease. However, little is known about MPR evaluation in comparison to fractional flow reserve (FFR), especially at 3 Tesla. Aim of our study was to compare quantitative MPR at 1.5 and 3 Tesla against FFR. Methods Thirty-four patients referred for coronary x-ray angio- graphy with suspected or known coronary artery disease underwent cardiac magnetic resonance imaging (CMR) at 1.5 and 3 Tesla, and additionally FFR measurement in LAD, CX and RCA. MPR was calculated in 544 myocar- dial segments at both field strenghts. FFR was measured in 109 coronary arteries with a cut-off value of ≤0.8 for relevant stenosis. Results In 38 coronary arteries (N=19 LAD, N=8 CX, N=11 RCA) a reduced FFR ≤0.8 was found. Receiver operator curve analysis yielded a higher area under the curve for 3 Tesla in comparison to 1.5 Tesla MPR (0.96 vs 0.65, p<0.001) resulting in higher values for sensitivity (90.5% vs. 61.9%) and specificity (100% vs. 76.9%), respectively. Conclusions Both field strengths, 1.5 and 3 Tesla, are capable to detect hemodynamic significant coronary artery stenoses using quantitative MPR analysis. The diagnostic accu- racy at 3 Tesla is however superior to 1.5 Tesla for MPR quantification. Funding The study was partially funded by a research grant of Guerbet (France). Published: 30 January 2013 doi:10.1186/1532-429X-15-S1-P199 Cite this article as: Bernhardt et al.: 1.5 and 3 Tesla quantification of myocardial perfusion reserve in comparison

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