Affordable Access

Publisher Website

Neanderthal and Denisovan retroviruses in modern humans

Authors
Journal
Current Biology
0960-9822
Publisher
Elsevier
Publication Date
Volume
23
Issue
22
Identifiers
DOI: 10.1016/j.cub.2013.10.028

Abstract

Summary In the June 5th 2012 issue of Current Biology, Agoni et al.[1] reported finding 14 endogenous retrovirus (ERV) loci in the genome sequences of Neanderthal and/or Denisovan fossils (both ∼40,000 years old) that are not found in the human reference genome sequence. The authors [1] concluded that these retroviruses were infecting the germline of these archaic hominins at or subsequent to their divergence from modern humans (∼400,000 years ago). However, in our search for unfixed ERVs in the modern human population, we have found most of these loci. We explain this apparent contradiction using population genetic theory and suggest that it illustrates an important phenomenon for the study of transposable elements such as ERVs.

There are no comments yet on this publication. Be the first to share your thoughts.