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Co-localization of GABA and neuropeptides in neocortical neurons

Authors
Journal
Trends in Neurosciences
0166-2236
Publisher
Elsevier
Publication Date
Volume
9
Identifiers
DOI: 10.1016/0166-2236(86)90026-3
Disciplines
  • Medicine

Abstract

Abstract A number of well known brain—gut peptides are found in the cerebral cortex. Those with the highest concentrations are almost always co-localized with both conventional transmitters (particularly GABA) and/or with other peptides within limited populations of cortical intrinsic neurons. The neurons containing both GABA and a peptide have similar morphology but particular sub-groups can be identified in terms of the peptides they contain and their synaptic targets. Levels of one cortical peptide, somatostatin, decline in Alzheimer's disease without a concomitant decline in GABA, with which it is co-localized. This and certain other puzzling features of peptide action and peptidergic cell morphology suggest that some may mediate trophic, and other effects on cortical neurons.

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