Abstract The preparation of immobilized ( R,R)-tartaric acid and ( S)-mandelic acid on spherical 5 μm silica gel via chiral alkoxy silanes is reported. The reactions of the chiral silanes were confirmed by elemental analysis, 13C-NMR and FT-IR. Subtraction of the FT-IR spectra of the unmodified silica gels from those of the modified ones results in the IR spectra of the chemically bonded chiral ligands. These were in good agreement with those of the starting compounds. Complexation of all bonded phases with Cu(II) or Cd(II) was examined by measuring the sorption isotherms at constant pH as well as the dependence of the metal ion concentration in the eluent on the retention of racemic compounds. Separation of amino alcohols on these chiral packings using ligand-exchange chromatography was found to be mainly controlled by the pH and the ionic strength of the eluent.