Affordable Access

Publisher Website

Prolyl-leucyl-glycinamide shares some effects with oxytocin but decreases oxytocin levels

Authors
Journal
Physiology & Behavior
0031-9384
Publisher
Elsevier
Publication Date
Volume
83
Issue
3
Identifiers
DOI: 10.1016/j.physbeh.2004.08.034
Keywords
  • Oxytocin
  • Mif-1
  • Plg
  • Tocinoic Acid
  • Nociceptive Thresholds
  • Blood Pressure
  • Spontaneous Motor Activity
  • Ischaemic Musculocutaneous Flap
  • Gastrin
  • Cholecystokinin
  • Corticosterone
  • Acth

Abstract

Abstract Oxytocin treatment in rats induces long-lasting antistress and growth promoting effects. This study investigated whether prolyl-leucyl-glycinamide (PLG) (the c-terminal tripeptide of oxytocin) or tocinoic acid (the ring structure of oxytocin) could induce some of these effects in male rats. For this purpose, PLG (2 or 10 mg/kg, s.c.) or tocinoic acid (1 mg/kg, s.c.) was administered to rats once a day for 3 or 5 days. Blood pressure, heart rate, spontaneous motor activity, nociceptive thresholds, and the survival of ischaemic musculocutaneous flaps were measured. In addition, endogenous oxytocin levels and plasma levels of some hormones known to be influenced by oxytocin were determined. PLG (2 mg/kg, s.c., but not 10 mg/kg, s.c.) decreased diastolic blood pressure ( p<0.05) and locomotor activity ( p<0.05). PLG (10 mg/kg, s.c.) decreased gastrin ( p<0.05) and endogenous oxytocin levels in plasma ( p<0.01). Tocinoic acid decreased locomotor activity ( p<0.05), but did not affect any of the other parameters measured. In conclusion, this study showed that both PLG and tocinoic acid decrease locomotor activity. In addition, PLG also induced some other effects similar to those induced by oxytocin treatment but when administered in high doses it decreased oxytocin levels.

There are no comments yet on this publication. Be the first to share your thoughts.