Tuberculosis is the leading cause of death due to a single organism; with a mortality of more than 3million people each year, worldwide. The emergence of multi-drug resistance and HIV/AIDS are the major causes of this problem. New therapeutic agents with a different mode of action, and thereby of resistance to Mycobacterium tuberculosis, the causative agent, are needed urgently. Amongst the methods used, the area of ethnopharmacology is explored in this study. Visits were performed to collect the plants used by traditional healers in 7 provinces of South Africa for the treatment of tuberculosis.