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Efficient coupling of α,α-dimethyl amino acid using a new chloro imidazolidium reagent, CIP

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
35
Issue
20
Identifiers
DOI: 10.1016/s0040-4039(00)76895-x

Abstract

Abstract CIP (2-chloro- 1,3-dimethylimidazolidium hexafluorophosphate) was an efficient coupling agent for N α-protected a-aminoisobutyric acid (Aib) in the presence of an additive. The reactivity was enhanced markedly by a catalytic amount of additive in the order of HOAt∼HODhbt > DMAP> HOBt. These couplings occurred without detectable racemization.

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