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Metal complexes of luteinizing hormone-releasing hormone (LHRH). Potentiometric and spectroscopic studies

Authors
Journal
Journal of Inorganic Biochemistry
0162-0134
Publisher
Elsevier
Publication Date
Volume
33
Issue
1
Identifiers
DOI: 10.1016/0162-0134(88)80030-8

Abstract

Abstract The results are reported of a potentiometric and spectroscopic study of the H +, Cu 2+, and Ni 2+ complexes of luteinizing hormone-releasing hormone (LHRH, HL) at 25°C and an ionic strength 0.10 mol dm −3 (KNO 3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions. With Cu 2+ the hormone has been shown to behave similarly to the thyrotropin releasing factor, forming a very stable [CuH −1L] complex involving coordination of three nitrogen donors: the N im atom of the imidazole side chain and the two amido-N atoms of the pyroglutamylhistidyl unit. With Ni 2+, coordination proceeds differently to give four nitrogen coordination.

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