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The synthesis of diaminopimelic acid containing peptidoglycan fragments using metathesis cross coupling

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
46
Issue
10
Identifiers
DOI: 10.1016/j.tetlet.2005.01.062
Keywords
  • Peptidoglycan
  • Amino Acid
  • Cross Metathesis
  • Meso-2
  • 6-Diaminopimelic Acid
Disciplines
  • Biology

Abstract

Abstract Properly protected diaminopimelic acid (DAP), a component of peptidoglycan of Gram-negative bacteria, was prepared by a metathesis cross coupling between properly protected allyl and vinyl glycine derivatives using Grubb’s second-generation catalyst followed by reduction of the double bond of the resulting compound. The DAP derivatives were used in the solution- and polymer-supported synthesis of biological active peptides.

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