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Copper-catalysed asymmetric 1,4-addition of organometallic reagents to 2-cyclohexenone using novel phosphine-phosphite ligands

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
11
Issue
15
Identifiers
DOI: 10.1016/s0957-4166(00)00262-7
Keywords
  • Articles

Abstract

Abstract A series of novel non-symmetrical phosphine-phosphite ligands 1– 10 have been tested in the copper-catalysed asymmetric addition of diethylzinc and triethylaluminium to 2-cyclohexenone. In all cases, excellent conversion and regioselectivities for the 1,4-product were found. Good enantiomeric excesses (up to 62%) were obtained when triethylaluminium was used as the alkylating reagent.

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