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Germinal center reaction: antigen affinity and presentation explain it all

Authors
Journal
Trends in Immunology
1471-4906
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.it.2014.06.001
Keywords
  • Germinal Center
  • Affinity Maturation
  • Antigen Presentation
  • Tfh Cells

Abstract

The selection and expansion of B cells undergoing affinity maturation in the germinal center is a hallmark of humoral immunity. A recent paper in Nature provides new insights into the relationships between the affinity of the immunoglobulin receptor for antigen, the ability of B cells to present antigen to T cells, and the processes of selection, mutation, and clonal expansion in the germinal center.

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