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The genetic kaleidoscope of vision

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Abstract

Site-specific phenotypic effects of the 73 known alleles in the rhodopsin gene that cause retinal degeneration are difficult to interpret because most alleles are documented in only one case or one family, which means variation in effects could actually arise from interactions with other loci. However, sample sizes necessary to detect epistatk. interaction may place an answer to this question beyond our grasp.

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