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Phenolic glycosides fromAlangium salviifoliumleaves with inhibitory activity on LPS-induced NO, PGE2, and TNF-αproduction

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
19
Issue
15
Identifiers
DOI: 10.1016/j.bmcl.2009.05.070
Keywords
  • Alangium Salviifolium
  • Alangiaceae
  • Phenolic Glycosides
  • Anti-Inflammatory

Abstract

Abstract Three new phenolic glycosides, salviifosides A−C ( 13), and three known compounds salicin ( 4), kaempferol ( 5), and kaempferol 3- O-β- d-glucopyranoside ( 6) were isolated from the leaves of Alangium salviifolium (L.f.) Wangerin (Alangiaceae). The structures of the new metabolites were determined on the basic of spectroscopic analyses including two dimensional NMR. The anti-inflammatory activities of new compounds ( 1− 3) were investigated on lipopolysaccharide (LPS)-induced murine macrophage cells line, RAW 264.7. Salviifoside B ( 2) potentially inhibits the productions of nitric oxide (NO), prostaglandin E 2 (PGE 2), and tumor necrosis factor-α (TNF-α).

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