Abstract Differences in abilities and preferences exist between left-handers who both write and throw with their left hands ( consistent left-handers) and those who write with their left hand but prefer to throw with their right ( inconsistent left-handers). It is also known that many left-handers are pressured to switch to right-hand writing, and that these pressures can lead to a right shift attempt. The present study is the first to explore the joint effects of the consistent/inconsistent left-handedness dichotomy, right shift attempt history, and lateral preference profiles. Testing 379 Canadian adults between the ages of 18 and 94 indicated that, while both types of left-handers were equally likely to experience a right shift attempt, the inconsistent left-handers were more likely to successfully switch to right-hand writing. Further analyses revealed that throwing hand was more associated than writing hand with the direction of sidedness for a lateral preference index based upon eye, foot, and ear preferences. More specifically, right-hand throwers were much more likely to have a rightward lateral preference score than were left-hand throwers, regardless of current preferred writing hand. Overall, the results support an hypothesis that the left-handers who are least likely to submit to rightward switch pressures are those with the strongest, most consistent left-sided lateral preference profile.