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Effect of steroids, including progestin and estrogen components of oral contraceptive drugs, on the esterase activity of thrombin

Authors
Journal
Thrombosis Research
0049-3848
Publisher
Elsevier
Publication Date
Volume
4
Issue
4
Identifiers
DOI: 10.1016/0049-3848(74)90231-x

Abstract

Abstract TAME esterase activities of bovine and human thrombin are accelerated in the presence of certain steroids. Steroids of the androstane series are the most active, those of the pregnane series are less acceleratory, and the natural estrogens are not acceleratory. However, some progestin and estrogen analogs, utilized as components of oral contraceptives, significantly increase the TAME esterase activity of thrombin. The conformation of the steroid nucleus and the nature and configuration of substituent groups are important in determining whether a steroid is acceleratory or non-acceleratory in the thrombin esterase assay system.

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