Affordable Access

Publisher Website

Homologated aza analogs of arabinose as antimycobacterial agents

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
8
Issue
3
Identifiers
DOI: 10.1016/s0960-894x(98)00017-1
Disciplines
  • Design

Abstract

Abstract A series of hydrolytically-stable aza analogs of arabinofuranose was prepared and evaluated against Mycobacterium tuberculosis and M. avium. The compounds were designed to mimic the putative arabinose donor involved in biogenesis of the essential cell wall polysaccharide, arabinogalactan. Though most compounds displayed little activity in cell culture, one compound showed significant activity in infected macrophage models.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Homologated aza analogs of arabinose as antimycoba...

on Bioorganic & Medicinal Chemist... Feb 03, 1998

6-Oxo and 6-thio purine analogs as antimycobacteri...

on Bioorganic & Medicinal Chemist... Apr 01, 2013

Lead optimization of 1,4-azaindoles as antimycobac...

on Journal of Medicinal Chemistry Jul 10, 2014
More articles like this..