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Childhood-Onset Schizophrenia: Timely Neurobiological Research

Authors
Journal
Journal of the American Academy of Child & Adolescent Psychiatry
0890-8567
Publisher
Elsevier
Publication Date
Volume
33
Issue
6
Identifiers
DOI: 10.1097/00004583-199407000-00001
Keywords
  • Schizophrenia
  • Brain Imaging
  • Genetics
Disciplines
  • Biology

Abstract

ABSTRACT Objective To review timely research on childhood-onset schizophrenia in view of advances in biological research on, and neurodevelopmental theories of, the later-onset disorder. Method Research issues are outlined including further clarification of ICD- and DSM-defined childhood schizophrenia, and differentiation from autism “spectrum” and other subtle, chronic developmental disorders. Key neurobiological advances are reviewed for which child studies are relevant and feasible. Conclusion: It is anticipated that narrowly defined childhood-onset schizophrenics will constitute a predominately male population. A high rate of family illness or chromosomal and/or brain developmental abnormalities, which will be instructive regarding the pathophysiology of later-onset schizophrenia, is expected.

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