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Insights into redox sensing metalloproteins inMycobacterium tuberculosis

Authors
Journal
Journal of Inorganic Biochemistry
0162-0134
Publisher
Elsevier
Volume
133
Identifiers
DOI: 10.1016/j.jinorgbio.2013.11.003
Keywords
  • Mycobacterium Tuberculosis
  • Redox Sensing
  • Molecular Gas Sensing
  • Metalloproteins
  • Hypoxia
Disciplines
  • Biology

Abstract

Abstract Mycobacterium tuberculosis, the pathogen that causes tuberculosis, has evolved sophisticated mechanisms for evading assault by the human host. This review focuses on M. tuberculosis regulatory metalloproteins that are sensitive to exogenous stresses attributed to changes in the levels of gaseous molecules (i.e., molecular oxygen, carbon monoxide and nitric oxide) to elicit an intracellular response. In particular, we highlight recent developments on the subfamily of Whi proteins, redox sensing WhiB-like proteins that contain iron–sulfur clusters, sigma factors and their cognate anti-sigma factors of which some are zinc-regulated, and the dormancy survival regulon DosS/DosT–DosR heme sensory system. Mounting experimental evidence suggests that these systems contribute to a highly complex and interrelated regulatory network that controls M. tuberculosis biology. This review concludes with a discussion of strategies that M. tuberculosis has developed to maintain redox homeostasis, including mechanisms to regulate endogenous nitric oxide and carbon monoxide levels.

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