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Instrumental and pharmacological paradoxical sleep deprivation in mice: Strain differences

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
19
Issue
6
Identifiers
DOI: 10.1016/0028-3908(80)90022-2
Keywords
  • Sleep
  • Paradoxical Sleep Deprivation
  • Robound Effect
  • Inbred Strains Of Mice
  • Nialamide
  • Chlorimipramine
  • Methyl-Naphtyl-Aziridine
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Paradoxical Sleep (PS) deprivation was effected by instrumental and pharmacological methods in four inbred strains, C57BR, C57BL/6, BALB/c and SEC. Instrumental PS deprivation was achieved by the water tank method for 10–24hr. Chlorimipramine. methyl-naphtyl-aziridine and nialamide were also used to obtain 6–24 hr of PS suppression. Later PS rebound was proportional to the duration of PS deprivation but different among strains. In BALB/c and SEC mice, pharmacological deprivation up to 24 hr did not provoke later PS rebound. A single injection of nialamide suppressed PS for about 24 hr, but was not followed by later PS rebound in any of the strains.

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