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Genetics and Alzheimer's disease: Notes of an environment watcher (with apologies to L. Thomas)

Authors
Journal
Neurobiology of Aging
0197-4580
Publisher
Elsevier
Publication Date
Volume
10
Issue
5
Identifiers
DOI: 10.1016/0197-4580(89)90093-6
Disciplines
  • Ecology
  • Geography
  • Medicine

Abstract

Abstract Support has recently been voiced for the genetic hypothesis of Alzheimer's disease; frequently at the expense of considerations of environmental factors. In the adult, genetic diseases rarely exist without modification by environment forces. Atherosclerosis leading to myocardial infarction may provide a useful model to consider genetic and environmental factors in Alzheimer's disease. Familial hypercholesterolemia produces a premature inherited form of myocardial infarction, whereas, atherosclerosis with myocardial infarction, seen in advanced age, relates more closely to environmental factors such as smoking, diet, etc.

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