Summary This is a report of a case of retrograde intussusception in a 16-month-old male infant in whom the pyloric end of the stomach was invaginated into the esophagus. The outstanding symptom was hematemesis. Despite the decrease in vomiting and the use of parenteral fluids, there was a continuous downhill course associated with an unrelieved high intestinal obstruction. At post mortem no etiologic factors were found which could have induced the development of this type of intussusception. The literature on cases of retrograde intussusception involving the stomach is reviewed and this case is an addition to the few cases reported.