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Loss of focal contacts accompanies:The density dependent inhibition of cell growth

Authors
Journal
Cell Biology International Reports
0309-1651
Publisher
Portland Press
Publication Date
Volume
13
Issue
4
Identifiers
DOI: 10.1016/0309-1651(89)90164-1

Abstract

Abstract The formation of focal contacts by fibroblast-like 3T3 and 9390 cells and endothelial XTH-2 cells was examined with the use of reflection interference contrast microscopy at different cell densities. It was found that cells density-inhibited in growth loose all focal contacts with the substratum. This observation explains the disappearance of stress fibers in density-inhibited cells, and also offers an explanation for the mechanism of density-dependent inhibition of proliferation of anchorage-dependent cells.

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