Affordable Access

Publisher Website

Feeding Impairments Associated with Plasma Sterols in Smith-Lemli-Opitz Syndrome

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.jpeds.2014.06.010
Disciplines
  • Biology
  • Chemistry
  • Design
  • Medicine

Abstract

Objective To quantitatively evaluate feeding impairment in children with Smith-Lemli-Opitz syndrome (SLOS) and to correlate feeding impairment with clinical and biochemical indices of disease severity. Study design The study subjects were 26 children with SLOS ranging in age from 0.4 to 19 years. Clinical severity was measured using an existing scoring system. We created a tool to quantitatively evaluate feeding. Plasma sterol concentrations were measured, and statistical associations (correlations) with feeding scores were calculated. Results Oral hyposensitivity or hypersensitivity, adverse behaviors, and risk for dysphagia were seen in ∼65% of the children with SLOS. Thirteen of the 26 children experienced failure to thrive, and 10 children required gastrostomy. Plasma concentration of 7-dehydrocholesterol, as a measure of severity, was correlated with total feeding score and oral function subcategory score (P < .001) and less so with oral structure score, adverse behaviors, or dysphagia. Correlations with cholesterol concentrations were less statistically significant. A plasma 7-dehydrocholesterol concentration >0.24 mmol/L or cholesterol concentration <1.95 mmol/L was predictive of gastrostomy tube use. Feeding impairments may improve with age. Conclusion Feeding impairment is common and complex in patients with SLOS. Our findings confirm that oral sensitivities, adverse feeding behaviors, and risk of oral phase dysphagia are amenable to quantitative evaluation and analysis. Feeding difficulties in children with SLOS are correlated with plasma sterol concentrations, suggesting a link between the biochemical severity of SLOS and feeding function. These findings expand the behavioral phenotype of SLOS and begin to provide insight into the biological causes of feeding difficulties.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Smith-Lemli-Opitz syndrome.

on Proceedings of the Royal Socie... September 1969

Smith-Lemli-Opitz syndrome.

on American Journal of Medical Ge... November 1987

Smith-Lemli-Opitz syndrome in Japan.

on American Journal of Medical Ge... Jan 06, 1998
More articles like this..