Abstract Nearly any person directly involved in the creation and production of polymers and many people around the world not involved whatsoever are familiar with the origins of the conception of fluoropolymers. After all, Teflon®, the trademark of polytetrafluoroethylene (PTFE) by DuPont, is renowned throughout the world. The classic story of the discovery of fluoropolymers is replete with the magical combination of brilliance and serendipity. The environment and the context in which the discovery occurred, however, is often overlooked. This chapter strives to place the invaluable discovery made by Roy Plunkett in the context of its times, events, and personalities. Plunkett’s finding is even more impressive, if at all possible, when viewed through the prism of context.