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Preparation of furans from alkynols utilizing palladium catalyzed intramolecular addition of alcohol to acetylene as a key reaction

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
41
Issue
18
Identifiers
DOI: 10.1016/s0040-4020(01)91384-5

Abstract

Abstract A procedure is described for the synthesis of furans from 3-alkyn-1,2-diols or 2-methoxy-3-alkyn-1-ols by palladium catalyzed intramolecular addition of alcoholic moiety to acetylene linkage followed by elimination of water or methanol. The intermediary 3-furylpalladiums can be trapped with allyl halides affording 3-allylfurans in good yields.

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