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Periodic Hyperammonemic Encephalopathy Associated With a Ureterosigmoidostomy

Authors
Journal
Mayo Clinic Proceedings
0025-6196
Publisher
Elsevier
Volume
64
Issue
6
Identifiers
DOI: 10.1016/s0025-6196(12)65343-9
Keywords
  • Case Report
Disciplines
  • Medicine

Abstract

Ureterosigmoidostomy, a urinary diversion procedure performed for treatment of congenital urologic defects or bladder cancer, may be associated with hyperammonemia. A delayed periodic encephalopathy, characterized by dysarthria, ataxia, and coma, developed in a 44-year-old woman who had undergone this procedure. Hyperammonemia-associated neurotoxicity resolved after surgical revision of the ureterosigmoidostomy to a ureteroileostomy. Therefore, a treatable episodic encephalopathy may occur in association with hyperammonemia in patients who have undergone ureterosigmoidostomy.

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