Affordable Access

Publisher Website

Mutagenicity of some substituted 1-phenyl-3,3-dimethyltriazenes:II. Chromosomal aberrations in human peripheral lymphocytes in vitro

Authors
Journal
Mutation Research Letters
0165-7992
Publisher
Elsevier
Publication Date
Volume
190
Issue
3
Identifiers
DOI: 10.1016/0165-7992(87)90026-1
Keywords
  • 1-Phenyl-3
  • 3-Dimethyltriazenes
  • Lymphocytes
  • Peripheral
  • Human
  • Chromosome Aberrations
  • 1-(4-Nitrophenyl)-3
  • 3-Dimethyltriazene

Abstract

Abstract The chromosome-breaking activity of four 1-(phenyl)-3,3-dimethyltriazenes was tested in vitro on human peripheral blood lymphocytes using S9 mix as a metabolic activation system. 1-(4-Nitrophenyl)-3,3-dimethyltriazene was the most active compound. The difference in the frequency of chromosomal aberrations in a test with and without metabolic activation was significant at the 1% level of significance. The lowest frequency of chromosomal aberrations was induced by 1-(4-methylphenyl)-3,3-dimethyltriazene which, under the conditions of this experiment, is the least stable and probably rapidly degraded to non-active compounds. The chromosomal aberrations were also induced by 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(4-bromophenyl)-3,3-dimethyltriazene, this activity was unrelated to metabolic activation.

There are no comments yet on this publication. Be the first to share your thoughts.